Maison des Chevaliers de Saint-Jean (House of the St. John's Knights) is one of Colmar's most important historical monuments and was built in 1608 by the architect Albert Schmidt, who also created the House of Heads and the House of Arcades. The building was dismantled in the 19th century and then rebuilt identically. Despite its name, the house never belonged to the Johannites and there is no real reason to call it the house of the St. John's Knights.

The architecture of this house is reminiscent of Venetian palaces, with a two-floor gallery of arched arcades, surmounted by a stone balustrade, which links together two buildings. One side of the building overlooks the road and the other the inner courtyard.

Today, the house still remains an architectural mystery, as no one can explain why it bears this name.